St John’s wort greatly decreases the plasma concentrations of oral S-ketamine

10 06 2011

Since both of these drugs are taken for anti-depressant purposes, it may be helpful to know that St. John’s Wort may decrease the effectiveness of ketamine:

Link: Fundamental & Clinical Pharmacology




Interview With a Ketamine Chemist

7 02 2011

Fascinating interview conducted by Hamilton Morris of Vice Magazine of a clandestine synthetic chemist specializing in arylcyclohexylamines (ketamine analogues).

With the 3-methoxys there is such incredible laughter and boundless sexual energy. […] I laughed until I had tears rolling down to my thighs!  The arylcyclohexylamines have a tremendous therapeutic potential, but they have a great abuse potential as well.

One methoxetamine user reported a dissociative-identity-disorder-esque psychotic episode. He impulsively fondled a stranger’s breasts, as if controlled by an external force. A nearly identical breast-fondling automatism was reported by John Lilly under the influence of ketamine. Perhaps the suppression of a breast-honking impulse is mediated by the NMDA receptor.
There’s a scientific study for you! We still have much to learn about the human brain.

Read the rest at Vice Magazine: INTERVIEW WITH A KETAMINE CHEMIST – Or to Be More Precise, an Arylcyclohexylamine Chemist – Vice Magazine

Psychedelic Science Conference Videos Online

2 12 2010

MAPS has just uploaded 85 of the presentations from the medical conference: Psychedelic Science In The 21st Century.

There should still be more to come too, but in this batch are many phenomenal talks.   Lots immensely fascinating scientific and medical topics as well as many videos on ayahuasca topics.

Some non-technical presentations I recommend are:

~Carolyn “Mountain Girl” Garcia – On The Bus
~Shulgin Tribute Banquet
~Robert Jesse – Closing Talk (on the betterment of well people)
~Andrew Weil M.D. – The Future of Psychedelic Research

…to name but a few for there are countless wonderful presentations to peruse:

Zoe7’s tales from the void

10 03 2010

Intrepid psychographer and author of Into The Void, Zoe7 poignantly and entertainingly muses upon his intensive psychonautic explorations, from the nature of  physics and perception to sex with trans-dimensional supermodels:

Isomer Design!

25 02 2009

Isomer Design is a site that hosts interactive versions and updates of Sasha Shulgin’s books.    It includes a brilliant tool for designing molecules based on various significant structures such as tryptamine and phenethylamine.

The site also sells a wicked detailed poster called Controlled Drugs and Substances Act: Schedules and Structures.


Psychoactive Terminography

19 01 2009

Steve Beyer authors a really nice blog called Singing To The Plants.  He has a hearty understanding of traditional approaches to entheogens and applies this to the pharmacological society we inhabit.   In a recent post titled
An Experiential Typology of Sacred Plants, he explores the need for a more refined and mature understanding of the describable differences between various, so-called, psychedelics:

Sacred plants such [the ayahuasca drink, the peyote cactus, and the teonanácatl mushroom] are commonly categorized by the chemical structure of their single active molecule.

[…]  there has been a pervasive assumption among academic researchers that the psychedelic experience is paradigmatically that of LSD, and that the experience of dimethyltryptamine, mescaline, and psilocybin can be lumped together with that of LSD under such rubrics as altered state of consciousness. Such terms refer vaguely to what the experiences of taking LSD, mescaline, dimethyltryptamine, and psilocybin — and maybe DOM and MDMA, but maybe not — presumably have in common. That there is such a common experience is simply assumed. Of current researchers, apparently only Richard Glennon has attempted a typology, based primarily on animal drug discrimination studies, which classifies these substances as hallucinogenic, central stimulant, or other, with some substances occupying more than one category.

I think we need a better typology than that. The goal should be to understand the phenomenology of the sacred plants under their ceremonial conditions of use, not when their single active molecules are ingested under experimental or recreational conditions.

He goes on to offer a 3D matrix of classification with axes being hallucinogenic, empathogenic and entheogenic, and focuses on the three main examples of psilocybe, ayahuasca and peyote.

While I really appreciate this approach phyto-maestro-Steve has embarked on, I do actually disagree with the semantics and particular choices of the 3 axes.

First off, psilocybin is extremely close to DMT (ayahuasca).  In fact, it’s just DMT with an extra hydroxy chunk on it that permits it to escape the digestive monoamine oxidizer.   So while this slight structural difference may lead to categorically different effects than pure DMT, I think they’re experiential similarity is more note-worthy than their difference.

But as per mescaline, salvia, THC, ibogaine, ketamine, etc, I think we do need to work on better observational descriptions, although we should dig deeper into the linguistic and poetic usages of ‘scientific’ terms, rather than rely solely on the recent tags of hallucinogen, empathogen, deleriant, psychointegrator, entheogen, etc.   They’re not necessarily dangerous words or anything, but neither are they very effective, however.

LINK:  Singing to the Plants


Network of Altered States

18 01 2009

The trip scenes from Ken Russel’s Altered States mixed with psytrance =


(8 min.)


The 1980 psy-fi cinema-romp, Altered States is an under-rated classic.   It was actually written by the same fellow who brought us the prophetic 1976 masterfilm, Network:

(15 sec)