Cheap, safe drug kills most cancers…

30 01 2007

but pharmaceutical companies won’t invest in clinical trials because because the molecule is not patantable, therefore not in their business interests.

This is big news.

DCA (dichloroacetate) kills cancer cells but leaves healthy ones alone (unlike chemotherapy). The drug has been around for too long to patented so big pharm co’s can’t make money on it, that leaves it up to privately funded clinical trials. But this may good in the long run because it means that once it is OK’ed it will be dirt cheap.

Info on the DCA research at University of Alberta here. You can also donate to the research through the univeristy, here.

Here are some press links for more info:
New Scientist
Science Daily
CBC News

Here’s a New Scientist editorial from the newest print edition:

Editorial: No patent? No cancer drug development.

SOME new cancer drugs emerge through better understanding of how the disease develops. Others work in ways we do not understand, and so give us fresh insight. It is rare to find a drug that sweeps away decades of assumptions and reveals a radical approach to treating all forms of the disease.

The drug is a simple, small molecule called dichloroacetate (DCA). Research in Canada led by Evangelos Michelakis of the University of Alberta has shown that it has promising anti-cancer properties. That’s not all. The drug’s mode of action is also generating excitement.

In 1930, biochemist Otto Warburg proposed that cells turn cancerous by changing the way they generate energy. Normally, cells rely on specialised organelles called mitochondria to supply their energy. Cancer cells switch to a process called glycolysis, which takes place in the body of the cell. It is an inefficient process, used by many bacteria – and marathon runners – when oxygen is in short supply.

Curiously, Warburg found that cancer cells continue to use glycolysis even when oxygen is plentiful. He argued that this fact, now called the Warburg effect, was a defining property of cancer cells. However, the idea did not catch on, not least because another famous biochemist, Hans Krebs, said the Warburg effect was only a symptom of cancer, not its primary cause. This scepticism was reinforced by the belief that cancer cells only switch to glycolysis because their mitochondria fail.

Enter DCA, which has been used for years to treat people with mitochondrial disease. The drug boosts the ability of mitochondria to generate energy. When given to cancer cells, it did the same: it seems that mitochondria in cancer cells are not irreparably damaged after all. What’s more, functioning mitochondria help to kill off these aberrant cells (see “Cheap, safe drug kills most cancers”).

When Michelakis tested the drug on cancer cells in culture, they died. When he gave it to rats with human tumours, the tumours shrank. It appears Warburg may well have been right that the switch to glycolysis is more than just a symptom of cancerous cells.

Best of all, DCA looks like a potential anti-cancer agent. It is cheap, does not appear to affect normal cells, we know its side effects, and it should work on all cancers. But there’s a hitch: it is an old drug and so cannot be patented. No pharmaceutical company is likely to fund costly clinical trials without some exclusive rights to make the drug.

This is not a new problem. Many drugs are left on the shelf because companies cannot make lots of money from them. It has happened with drugs for diseases that affect mainly poor people in developing countries, such as TB, though there are now an increasing number of partnerships between governments, charities and commercial companies to deal with these cases. Cancer, by contrast, is chiefly a disease of the rich, and testing DCA will need a one-off effort.

It is a safe bet that drug companies will be falling over themselves to find patentable compounds with a similar action to DCA. Any of these reaching the market will be hugely expensive. It would be a scandal if a cheap alternative with such astonishing potential were not given a chance simply because it won’t turn a big enough profit.

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One response

17 12 2008
joshjoshn

great story for more stories like that visit:
http://forums.cancer.vc

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